Researchers have uncovered that Tregs can instead stimulate the activation of a particular immune cell, which has a role in several inflammatory conditions, particularly in allergy.
(Meenu Sharma and Jagadeesh Bayry )
Human body naturally produces a different type of white blood cells (leukocytes). Of them, basophils share around 0.5% of total leukocytes in the blood- which provides protection against helminth parasites. Despite basophils are known since ages for their role in allergic and inflammatory diseases, how their activities are regulated and are kept in check still not understood.
Normally immune system guards our body against pathogens like bacteria and virus, and cleans them regularly. However, under certain conditions, immune system attacks our own body and those results in autoimmune and inflammatory diseases like diabetes, arthritis, and others. Therefore, there are peacekeepers in the body to make sure that our immune system does not attack our own body, organs and tissues. These peacekeepers are regulatory T cells or “Tregs” that block hyperactivation of immune system and thus prevent autoimmune diseases and inflammation. For that matter, Tregs-derived molecules are currently used in clinic for the immunotherapy of several diseases.
Thus by default, Tregs are known in the scientific community as ‘immunosuppressor’ cells, which ensure that autoimmune responses and inflammation are kept in check and hence safeguard our body. Now, researchers for the first time have uncovered that Tregs can instead stimulate the activation of a particular immune cell, which has role in several inflammatory conditions, particularly in allergy.
Dr. Jagadeesh Bayry’s team at Institut National de la Santé et de la Recherche Médicale (French National Institute of Health and Medical Research, INSERM), Paris, France- have discovered that Tregs instead of suppressing the activities of basophils, they trigger these cells to express activation markers, to secrete cytokines and support their allergic responses. These findings also explain why Tregs are unable to control allergic responses when we encounter various environmental allergens in our daily life.
“We have discovered that Tregs forget that they are supposed to be suppressors when mesmerized by basophils. Our findings revealed that Tregs instead of suppressive, they activate the basophils and thus highlights a ‘secret’ life and a special relationship of basophils with Tregs,” said Dr. Jagadeesh Bayry, study leader and co-author in this study.
Meenu Sharma, First author in this study, says, “this is the first ever study that revealed previously unknown aspect of Tregs. We have found unusual relationship between basophils and Tregs.”
“Ours is a fundamental immunology finding and has broad implication for the therapy of allergic diseases. In view of our current findings, we strongly urge the scientific community to target both Tregs and basophils in order to obtain maximum efficacy of immunotherapy,” said Dr. Bayry.
“This report will completely change our current default view on Tregs as immune suppressors. Because of these unexpected findings, the concept of Treg-based therapeutic approaches may need to be revisited for allergy and asthma, where basophils are one of the major players that drive the inflammation”, commented Prof. K. N. Balaji from Indian Institute of Science, India. He is not involved in this study.
The research team included Meenu Sharma, Mrinmoy Das, Emmanuel Stephen-Victor, Caroline Galeotti, Anupama Karnam, Mohan S. Maddur, Patrick Bruneval, Srini V. Kaveri, and Jagadeesh Bayry. These results were published in the journal “Science Immunology.” The study was funded by French National Institute of Health and Medical Research, European Commission collaborative Grant and Sorbonne University.